Endocrine Abstracts

Introduction: Dumping syndromes are common after bariatric surgery and can present diagnostic and therapeutic challenges in pregnancy.Case report: A 23-year-old female who underwent a RYGB surgery because of morbid obesity in 2013. She had no medical history of diabetes nor any other comorbidity related to obesity. Two years later, her weight had reduced from 128 to 76 kg and also her body mass index (BMI) from 43.8 to 26 kg/m2. She was treate...

For over 50 years the casuistic of patients with thyroid cancer registered in the Nuclear Medicine Department of the National Institute of Endocrinology in Bucharest, Romania, has over 12 000 cases. In the last 6 years, a total of 2580 new cases have been added. They are organized in a ‘classic file’ format. As a necessity and the first step in order to build a digital national database, we developed the BIOMAT-ENDO software as a Windows Forms application that stores...

Background: An increasingly recognized complication of Roux-en-Y Gastric Bypass (RYGB) surgery is the development of postprandial hypoglycaemia (PPH). However, there remains no agreed standard on how to diagnose this condition. Commonly used tests include a prolonged oral glucose tolerance test (POGTT) and mixed meal tolerance test (MMTT). Little is known regarding how these tests compare in the post-bariatric population.Methods: Ten patients who had con...

Case history: A 30-year old female presented with a 10-month history of enlarging neck mass, fatigue and weight gain. Assessment by her GP found her to have a large smooth goitre and biochemical hypothyroidism. The patient had a history of intestinal failure secondary to mitochondrial disorder. As a result of intestinal failure she was entirely dependent on parenteral nutrition and was intolerant of any oral intake, with venting of her stomach to reduce pain. She was referred ...

Cigarette smoke contains over 60 well established carcinogens. There are strong links between some of these carcinogens and various types of smoking-induced cancers. In this study we investigated whether cigarette smoke extracts (CSEs) affects the cell proliferation, migration, and invasion of BG-1 human ovarian cancer cells by alteration of epithelial-mesenchymal transition (EMT). We confirmed that CSEs increased the ovarian cancer cell viability in a dose-dependent manner. A...

Objective: Quality of life is currently considered a major factor in the assessment of disease outcome. The aim was to assess quality of life in acromegaly and the effect of somatostatin analogues on it.Design: This study included 101 patients with acromegaly, mean age 59.51±1.35 years (mean ± S.E.M.), with a disease duration of 12.88±0.96 years. All subjects completed the Acromegaly Quality of Life Questionnaire (AcroQoL) w...

Asfotase alfa (AA, STRENSIQ, Alexion Pharmaceuticals, Inc.) is the first FDA-Approved treatment for patients with hypophosphatasia, the result of a mutation in the tissue-nonspecific alkaline phosphatase (ALPL) gene. Because it contains the ALP active site, AA is able to catalyse the substrate as the antibody-conjugated ALP would within an assay. Therefore, AA present in a patient’s sample may generate a false positive or a false negative result. We investigated ...

GPR56 is an adhesion G-protein coupled receptor (GPCR), which we have shown to be the most abundant GPCR in mouse and human islets. The extracellular N-terminal domain of adhesion GPCRs contains a tethered agonist, buried within the GPCR autoproteolysis-inducing domain. Synthetic peptides mimicking tethered agonist sequences can activate a variety of adhesion GPCRs including GPR56. Here we investigated the effect of a GPR56 tethered agonist peptide, P7, on β-cell function...

Endometrial cancer is the most common gynaeological malignancy in the developed world: lifetime exposure to oestrogen is a key risk factor. Oestrogen action is mediated by ligand activated receptors encoded by the ESR1 (ERα) and ESR2 (ERß) genes: ERα plays a key role in regulating endometrial cell proliferation. ERß5, is a truncated variant isoform of ERß formed by alternative splicing of ESR2 that contains a DNA binding doma...

Introduction: Disorders of Sex Development (DSD) can be associated with an increased risk of germ cell tumours depending on the underlying diagnosis. To date however knowledge regarding the indications and timing of gonadectomy is lacking.Methods: The I-DSD Registry was interrogated for anonymised information regarding the diagnosis, karyotype, sex of rearing and timing of gonadectomy, if undertaken, of all individuals of any karyotype who were over the ...